Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai
In this episode of BioTalk Unzipped, hosts Gregory Austin and Dr. Chad Briscoe interview Asst. Professor Pin-Kuang Lai from Stevens Institute of Technology about his keynote speech at AAPS NBC 2025 and the intersection of AI and molecular engineering, particularly in predicting the viscosity of monoclonal antibodies. They discuss the challenges of high concentration formulations, the importance of AI validation, and the future of formulation development. Lai shares insights from his international research journey and collaborations with pharmaceutical companies, as well as opportunities for students interested in this field.
00:00 Preview & Intro
01:58 Deep Viscosity and AI in Antibody Development
04:39 AI Validation and Model Reliability
07:12 International Journey and Collaborative Research
08:42 Future of Formulation Development
10:30 AAPS NBC Experience
11:30 Academic vs. Industry Career Paths
12:31 Collaboration with Pharmaceutical Companies
13:59 Modeling Protein Aggregation Challenges
14:43 Student Engagement and Research Opportunities
15:45 Expanding Applications of Machine Learning
Dr. Pin-Kuang Lai
https://www.linkedin.com/in/pin-kuang-lai/
Stevens Institute of Technology - https://www.stevens.edu/
Dr. Lai’s Publications - https://www.linkedin.com/in/pin-kuang-lai/details/publications/
The DeepViscosity Model - https://devpred.onrender.com/DeepViscosity
Dr. Chad Briscoe
https://www.linkedin.com/in/chadbriscoe/
Celerion - https://www.celerion.com/
Gregory Austin
https://www.linkedin.com/in/gregoryaustin1/
Celerion - https://www.celerion.com/
